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doi: 10.1242/jcs.115.6.1231 96 ExleyR

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Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage

7 , 75 , 76 Elaborating further, in the synovial capsule these oxidants coordinate synergistic effects on chondrocytes because they initiate inflammatory reactions which dysregulate the ECM turnover, ultimately destroying cartilage